In the short term, islet transplant recipients do well. However, longer term, we see cases of rejection increase.Transplant rejection is a major cause of graft loss and loss of function. It is important that we develop a means of predicting the likelihood of rejection, so that we can intervene.We built on existing research and developed a consistent method of using flow cytometry to analyze the immune-cell-count, and subsets of immune cells present in the blood of transplant recipients. This involved the standardization of a number of factors, such as sample handling and instrument set up.We found that this method was easy to use and produced consistent results across a number of samples.Importantly, we also found that this method had a very limited impact on the patient – only 1.5mL of blood was required for testing.” Reviewed by Kate Anderton, B.Sc. (Editor)May 29 2019Researchers from The Westmead Institute for Medical Research have developed a standardized method of measuring the immune response in islet transplant recipients, helping predict patient outcomes.Islet transplantation is a frontier therapy for type 1 diabetes with notable success in hypoglycaemic patients, where pancreatic beta cells from a donor are transplanted into a recipient, enabling the body to produce insulin, and regulate blood sugar.Transplant recipients are given immunosuppressant medication to prevent the immune system from attacking and destroying the transplant. However, rejection may still occur in certain instances.Lead researcher Dr Min Hu and her team aimed to standardize a method using flow cytometry – technology that detects and measures the characteristics of a group of cells – to analyze the immune cells present in blood samples.The research built on existing findings, which established that certain profiling panels (sets of characteristics that are detected and measured) could be used on flow cytometers to monitor the major immune cells involved in transplantation.Dr Hu said: Related StoriesComplement system shown to remove dead cells in retinitis pigmentosa, contradicting previous researchOne-fifth of U.S. surgeons still ‘overusing’ riskier method to create kidney dialysis access, study findsFight for Sight poll: Brits put their eyesight at risk through unsafe contact lens habitsIslet transplantation is currently only administered in clinical trials. Dr Hu said the research findings could be used in conjunction with current clinical trials to monitor patients after a transplant.”Islet transplantation is an important breakthrough for people with type 1 diabetes. If the transplant is tolerated, it can significantly improve the patients’ quality of life.”Unfortunately, we currently have no method of predicting how a patient will respond to a transplant.”By using this standardized method of flow cytometry to monitor changes in the immune system, this research could help predict whether a patient will reject a transplant, enabling early intervention, and the potential development of other solutions to stop rejection from occurring.”The paper was published in PLOS ONE.Source:Westmead Institute for Medical ResearchJournal reference:Hu, M. et al. (2019) Standardisation of flow cytometry for whole blood immunophenotyping of islet transplant and transplant clinical trial recipients. PLOS ONE. doi.org/10.1371/journal.pone.0217163.
Despite best efforts by rheumatologists and patients to find an effective arthritis treatment and management strategy, there are still many patients who seek additional relief for chronic symptoms. It’s alarming that so many arthritis patients use medical marijuana and cannabidiol products in the absence of high quality evidence about their safety, effectiveness, and appropriate dosing. This underscores the urgent need to conduct randomized, controlled trials to study their effectiveness at addressing symptoms common to arthritis as well as their potential to interact with other medications. Moreover, it’s concerning that patients may not be discussing their use of these products to augment or replace other arthritis treatments with their health care team.”W. Benjamin Nowell, Ph.D., Director of Patient-Centered Research at CreakyJoints and an ArthritisPower co-principal investigator and poster author Jun 20 2019On June 13, CreakyJoints®, a Global Healthy Living Foundation patient community, will present a poster at the Annual European Congress of Rheumatology (EULAR 2019) meeting in Madrid, Spain. Two additional abstracts were accepted for publication.The poster titled, “Patients’ Perceptions and Use of Medical Marijuana,” found that more than half (57.3%) of arthritis patients (N=1,059) have reported trying marijuana (THC) and/or cannabidiol (CBD) products for a purpose they perceived as medical. Of those who use THC regularly for medical reasons 62 percent reportedly use THC at least once daily. Among the most commonly cited reasons for stopping use were illegality (31.2%) of THC and cost (32.5%) of CBD. Despite those barriers, most participants who tried THC or CBD said that it improved their symptoms (THC= 97.1%, CBD=93.7%) and/or their condition (THC= 96.1%, CBD=93.1%). Pain and sleep disturbance were the main symptoms participants sought to relieve with these products and many used them in lieu of prescribed or over-the-counter medications. Related StoriesStill-to-be-approved drug proves to be new option for treating active rheumatoid arthritisResearchers develop NO-scavenging hydrogel for treatment of rheumatoid arthritisPromising methods for early detection and treatment of rheumatoid arthritisThe survey found that only two-thirds (64.6%) of participants reported telling their HCP about their THC or CBD use and of those more than half did not receive any information from their healthcare provider about safety, effectiveness or dosing, possibly because such little research is available. Of those that did receive advice, most reported that their HCP did not consider their use of THC or CBD when making other treatment changes. Whether they had used THC or CBD for medical reasons or not, most patients (THC=65.5%, CBD=55.6%) expressed wanting more information about them, including on their effectiveness and interaction with other medications from their health care provider or online educational resources.Utilizing the ArthritisPower® research registry, which now includes more than 19,000 consented participants, the 77-item survey included 1,059 participants who were ≥ 19 years old, lived in the United States, and reported physician-diagnosed rheumatoid or musculoskeletal disease. The survey also required participants to report their current health status (NIH PROMIS Global Health), use and perceptions of THC/CBD, and related information needs. The complete survey results are available in the poster, upon request.Overview of CreakyJoints data at EULAR 2019 Patients’ Perceptions and Use of Medical Marijuana Identifier: THU0644 Poster presentation: June 13, 2019 at 11:45 a.m. CET The Patient Experience: A Process Evaluation of a Pilot Pragmatic Using Remote Monitoring of Symptoms Identifier: AB1284, published abstract Patient Preferences for the Use of Digital Tools and Social Media in Diet and Exercise Interventions Identifier: AB1222, published abstract Source:CreakyJoints read more
The Cyberabad cops have mooted a nodal agency to keep an eye on likely trouble-makers among the three lakh private security personnel working in the IT hubs of Madhapur and Gachibowli.“There are 2-3 lakh security guards working in scores of IT firms in the IT hub areas. We need to create a nodal agency to maintain a data bank, with information on the security personnel. It will keep a record of their errant and criminal behaviour,” Cyberabad Commissioner of Police, V. C. Sajjanar, has said.This data will be handy for companies to verify their credentials and keep them off the rolls. Sajjannar was addressing a meeting of the Society for Cyberabad Security Council (SCSC) to take stock of the security preparedness in the IT areas.The SCSC has been established by the IT companies to coordinate with the local police, to ensure safety and security of people and properties.He offered to train all the security guards in improving their tactics and intelligence gathering skills. “It will help them quickly get in touch with the police if they find something suspicious,” he said.Stating that CCTVs played a big role in solving cases, he asked the heads of security wings of various IT firms to collect donations in order to have more closed-circuit cameras in the Cyberabad area.“We have installed 85,000 cameras in the last 18 months. There is a need for another 1,15,000 cameras to cover the whole area,” he said. COMMENTS SHARE SHARE EMAIL COMMENT SHARE Hyderabad Published on June 19, 2019 Telangana read more