Reviewed by Alina Shrourou, B.Sc. (Editor)Apr 2 2019Research at St. Jude Children’s Research Hospital has identified a genomic risk factor associated with stroke in childhood cancer survivors. The findings were announced today at a press conference as part of the American Association for Cancer Research annual meeting in Atlanta.This investigation draws on whole genome sequencing and other data gathered longitudinally through the St. Jude Lifetime Cohort (SJLIFE) study. The purpose of SJLIFE is to learn about the health of adult survivors of childhood cancer and to reduce the late effects of childhood cancer treatments.”Long-term survivors of childhood cancer are known to be at an increased risk of stroke, which is often attributed to their prior cancer treatment,” said first author Yadav Sapkota, Ph.D., of the St. Jude Department of Epidemiology and Cancer Control. “But we observed variation in risk that suggested there may be an underlying genetic component.”To study the risk of stroke, Sapkota and his colleagues focused on 686 childhood cancer survivors in the cohort treated with cranial radiation therapy. Higher doses of radiation have been previously correlated with risk of stroke. However, the researchers wanted to understand why some patients treated with high doses do not experience a stroke, while other patients do even when they are treated at lower doses.”This is one of the first studies to evaluate the genomic underpinnings of stroke in such a robust cohort,” Sapkota said. “Ultimately our findings help determine who is at a greater risk so we can intervene on modifiable lifestyle and other factors that are known to affect the risk of stroke.”The genomic data generated through this research is freely available to researchers on the St. Jude Cloud platform, a data-sharing resource pioneered by St. Jude and available to the global research community. St. Jude Cloud is one of the world’s largest repositories of pediatric genomics data and offers a suite of unique analysis tools and visualizations.Related StoriesTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerUsing machine learning algorithm to accurately diagnose breast cancerStudy reveals link between inflammatory diet and colorectal cancer riskKey findings from the study include: In addition to the dose level of cranial radiation therapy that increases stroke risk up to 11 fold, variants on a chromosomal region called 5p15.33 increase risk approximately three-fold overall. This result suggests that testing for variants of 5p15.33 may be useful for identifying patients who, when treated with cranial radiation therapy, will be at a high risk of stroke as adults. This is the first study to link the chromosomal region with an increased risk of stroke. These variants in 5p15.33 are found to elevate stroke risk approximately five-fold among childhood cancer survivors treated with intermediate dose (25-50 Gray) of cranial radiation therapy. This suggests that among those treated with cranial radiation therapy, 5p15.33 may modify the effect of the treatment on stroke risk. The researchers replicated the finding in two independent groups of survivors from SJLIFE, consisting of survivors of African ancestry who received cranial radiation therapy and survivors of European descent who did not receive cranial radiation therapy. Results of the replication analysis suggest that a combination of cranial radiation therapy and genetic factors can greatly increase childhood cancer survivors’ risk for developing stroke. Source:https://www.stjude.org/media-resources/news-releases/2019-medicine-science-news/aacr-genetic-study-identifies-risk-factor-for-stroke-among-cancer-survivors.html This research is included in a poster session to be held Wednesday, April 3, 2019, as part of the AACR meeting. Additionally, SJLIFE is one of the projects for which the St. Jude Survivorship Research Team was awarded the 2019 AACR Team Science Award. To date, through SJLIFE, more than 4,300 survivors and 580 control cases have undergone comprehensive evaluations of cardiac, reproductive, neuromuscular, neurocognitive and psychosocial functions.
In the short term, islet transplant recipients do well. However, longer term, we see cases of rejection increase.Transplant rejection is a major cause of graft loss and loss of function. It is important that we develop a means of predicting the likelihood of rejection, so that we can intervene.We built on existing research and developed a consistent method of using flow cytometry to analyze the immune-cell-count, and subsets of immune cells present in the blood of transplant recipients. This involved the standardization of a number of factors, such as sample handling and instrument set up.We found that this method was easy to use and produced consistent results across a number of samples.Importantly, we also found that this method had a very limited impact on the patient – only 1.5mL of blood was required for testing.” Reviewed by Kate Anderton, B.Sc. (Editor)May 29 2019Researchers from The Westmead Institute for Medical Research have developed a standardized method of measuring the immune response in islet transplant recipients, helping predict patient outcomes.Islet transplantation is a frontier therapy for type 1 diabetes with notable success in hypoglycaemic patients, where pancreatic beta cells from a donor are transplanted into a recipient, enabling the body to produce insulin, and regulate blood sugar.Transplant recipients are given immunosuppressant medication to prevent the immune system from attacking and destroying the transplant. However, rejection may still occur in certain instances.Lead researcher Dr Min Hu and her team aimed to standardize a method using flow cytometry – technology that detects and measures the characteristics of a group of cells – to analyze the immune cells present in blood samples.The research built on existing findings, which established that certain profiling panels (sets of characteristics that are detected and measured) could be used on flow cytometers to monitor the major immune cells involved in transplantation.Dr Hu said: Related StoriesComplement system shown to remove dead cells in retinitis pigmentosa, contradicting previous researchOne-fifth of U.S. surgeons still ‘overusing’ riskier method to create kidney dialysis access, study findsFight for Sight poll: Brits put their eyesight at risk through unsafe contact lens habitsIslet transplantation is currently only administered in clinical trials. Dr Hu said the research findings could be used in conjunction with current clinical trials to monitor patients after a transplant.”Islet transplantation is an important breakthrough for people with type 1 diabetes. If the transplant is tolerated, it can significantly improve the patients’ quality of life.”Unfortunately, we currently have no method of predicting how a patient will respond to a transplant.”By using this standardized method of flow cytometry to monitor changes in the immune system, this research could help predict whether a patient will reject a transplant, enabling early intervention, and the potential development of other solutions to stop rejection from occurring.”The paper was published in PLOS ONE.Source:Westmead Institute for Medical ResearchJournal reference:Hu, M. et al. (2019) Standardisation of flow cytometry for whole blood immunophenotyping of islet transplant and transplant clinical trial recipients. PLOS ONE. doi.org/10.1371/journal.pone.0217163. read more
Despite best efforts by rheumatologists and patients to find an effective arthritis treatment and management strategy, there are still many patients who seek additional relief for chronic symptoms. It’s alarming that so many arthritis patients use medical marijuana and cannabidiol products in the absence of high quality evidence about their safety, effectiveness, and appropriate dosing. This underscores the urgent need to conduct randomized, controlled trials to study their effectiveness at addressing symptoms common to arthritis as well as their potential to interact with other medications. Moreover, it’s concerning that patients may not be discussing their use of these products to augment or replace other arthritis treatments with their health care team.”W. Benjamin Nowell, Ph.D., Director of Patient-Centered Research at CreakyJoints and an ArthritisPower co-principal investigator and poster author Jun 20 2019On June 13, CreakyJoints®, a Global Healthy Living Foundation patient community, will present a poster at the Annual European Congress of Rheumatology (EULAR 2019) meeting in Madrid, Spain. Two additional abstracts were accepted for publication.The poster titled, “Patients’ Perceptions and Use of Medical Marijuana,” found that more than half (57.3%) of arthritis patients (N=1,059) have reported trying marijuana (THC) and/or cannabidiol (CBD) products for a purpose they perceived as medical. Of those who use THC regularly for medical reasons 62 percent reportedly use THC at least once daily. Among the most commonly cited reasons for stopping use were illegality (31.2%) of THC and cost (32.5%) of CBD. Despite those barriers, most participants who tried THC or CBD said that it improved their symptoms (THC= 97.1%, CBD=93.7%) and/or their condition (THC= 96.1%, CBD=93.1%). Pain and sleep disturbance were the main symptoms participants sought to relieve with these products and many used them in lieu of prescribed or over-the-counter medications. Related StoriesStill-to-be-approved drug proves to be new option for treating active rheumatoid arthritisResearchers develop NO-scavenging hydrogel for treatment of rheumatoid arthritisPromising methods for early detection and treatment of rheumatoid arthritisThe survey found that only two-thirds (64.6%) of participants reported telling their HCP about their THC or CBD use and of those more than half did not receive any information from their healthcare provider about safety, effectiveness or dosing, possibly because such little research is available. Of those that did receive advice, most reported that their HCP did not consider their use of THC or CBD when making other treatment changes. Whether they had used THC or CBD for medical reasons or not, most patients (THC=65.5%, CBD=55.6%) expressed wanting more information about them, including on their effectiveness and interaction with other medications from their health care provider or online educational resources.Utilizing the ArthritisPower® research registry, which now includes more than 19,000 consented participants, the 77-item survey included 1,059 participants who were ≥ 19 years old, lived in the United States, and reported physician-diagnosed rheumatoid or musculoskeletal disease. The survey also required participants to report their current health status (NIH PROMIS Global Health), use and perceptions of THC/CBD, and related information needs. The complete survey results are available in the poster, upon request.Overview of CreakyJoints data at EULAR 2019 Patients’ Perceptions and Use of Medical Marijuana Identifier: THU0644 Poster presentation: June 13, 2019 at 11:45 a.m. CET The Patient Experience: A Process Evaluation of a Pilot Pragmatic Using Remote Monitoring of Symptoms Identifier: AB1284, published abstract Patient Preferences for the Use of Digital Tools and Social Media in Diet and Exercise Interventions Identifier: AB1222, published abstract Source:CreakyJoints read more
Being a couch potato: Not getting enough physical activity or too much bed rest following an injury, illness or surgery weakens bones over time. This article is for informational purposes only and is not meant to offer medical advice. by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoLivestlyThe List Of Dog Breeds To Avoid At All CostsLivestlyUndoBirch Gold GroupThis IRS Tax Law is Sweeping the U.S.Birch Gold GroupUndo Download a helpful brochure from Osteoporosis Canada on managing osteoporosis through exercise. Sex: Women are more likely to develop osteoporosis than men, because women have less bone tissue and lose bone faster after menopause. Osteoporosis is a common disease that makes bones weak, thin, brittle and more likely to break. The condition typically occurs in women after menopause and can increase the risk of fractures, especially in the hip, spine and wrist, according to the National Institutes of Health. The condition is often called a “silent disease” because bone loss can happen slowly and without any warning signs. People may not be aware they have osteoporosis until they break a bone, lose height or develop hunched posture. About 10 million Americans have osteoporosis, and another 44 million have low bone mass, or osteopenia, placing them at increased risk for osteoporosis, according to the National Osteoporosis Foundation.Advertisement There are a number of factors that may lead to osteoporosis, said Dr. Harold Rosen, an endocrinologist and director of the Osteoporosis Prevention and Treatment Center at Beth Israel Deaconess Medical Center in Boston. One such factor is the accelerated bone loss that occurs after menopause, he said. Men also lose bone as they age, normally once they’re in their 60s and 70s, Rosen said. Some men think osteoporosis affects only women, but it strikes men too, he explained. Low calcium intake and low vitamin D levels in the body can also lead to bone loss, Rosen told Live Science. The body needs a good supply of calcium and other minerals to form bone, and vitamin D helps absorb calcium from food and incorporate the nutrient into bone. In addition, unhealthy habits, such as smoking and excessive drinking, can speed up bone loss, he said. Bone Density Decreases in SpaceBone loss is a serious issue that has plagued astronauts since the dawn of the Space age. In the microgravity environment bones are remodeled with a decrease in mineral density. Good nutrition, increased vitamin D intake and exercise are used to battle the issue aboard the ISS.Volume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Better Bug Sprays?01:33关闭选项Automated Captions – en-US facebook twitter 发邮件 reddit 链接https://www.livescience.com/65900-osteoporosis.html?jwsource=cl已复制直播00:0002:4102:41Your Recommended Playlist01:33Better Bug Sprays?04:24Sperm Whale Befriends Underwater Robot01:08Why Do French Fries Taste So Bad When They’re Cold?00:29Robot Jumps Like a Grasshopper, Rolls Like a Ball00:29Video – Giggly Robot02:31Surgical Robotics关闭 Family history: People whose parents had a hip fracture may be more likely to develop the disease. How bone changes over time The body is continually breaking down small areas of old bone tissue, a process called bone resorption, and replacing that old tissue with new bone tissue. During childhood and adolescence, new bone is deposited faster than old bone is removed. This makes bones larger, heavier and denser. Peak bone mass, or when bones reach their maximum density and strength, typically occurs around age 30 for both sexes. Around age 35, bone breakdown occurs faster than the replacement by new bone, causing a gradual loss of bone mass, according to the National Institute on Aging. Women undergo more-rapid bone loss in the first few years after menopause (around age 51) than in their 30s and 40s because the ovaries produce much less estrogen, a hormone that protects against bone loss, according to The American College of Obstetricians and Gynecologists. Men in their 50s and 60s also start to lose bone mass, but at a slower rate than women do. It’s not until ages 65 to 70 that men and women begin losing bone mass at about the same rate. For that reason, osteoporosis is more common in women. The condition affects about 25% of women and 5% of men ages 65 and over, according to the Centers for Disease Control and Prevention. Can osteoporosis be prevented? The more bone a person builds early in life, the better that individual can resist bone loss later on. Prevention should start when people are younger, during their peak bone-building years, with the following steps, according to the National Osteoporosis Foundation: Getting regular weight-bearing exercise. Ethnicity: White and Asian women have the highest risk of osteoporosis, while African American and Hispanic women have a lower risk. Nutrition: Eating a diet that’s low in calcium and vitamin D increases osteoporosis risk. Maintaining a healthy lifestyle, such as avoiding smoking and limiting alcohol consumption, reduces bone loss. Review this list of calcium-rich foods from the University of California, San Francisco Medical Center. Osteoporosis treatment and medications People with advanced osteopenia as well as those with osteoporosis need medication to reduce their risk of fractures. Bisphosphonates are usually the first drugs used to treat osteoporosis, but while they help slow bone loss, they don’t help build new bone. These drugs include alendronate (Fosamax), risedronate (Actonel) and ibandronate (Boniva). Studies have shown that alendronate can reduce the risk of spine and hip fractures by up to 50%, Rosen said. Once a person has started treatment for osteoporosis, bone-density testing should be repeated every two to three years to monitor how the density is changing and whether treatment is working, Rosen said. For severe osteoporosis, patients may need one of three medications given by injection that actually build new bone, Rosen said. These include teriparatide (Forteo), abaloparatide (Tymlos) and romosozumab (Evenity). But after a year on these bone-building drugs, a patient needs to take bisphosphonates; otherwise, all the bone-density gains will be lost, Rosen said. In addition to medication, people with osteoporosis should aim to include 1,200 milligrams of calcium a day in their diet, from food or supplements (preferably calcium citrate), Rosen said. He also recommends taking 1,500 to 2,000 International Units (IU) of supplemental vitamin D each day. Being physically active is also beneficial for people with osteoporosis. Rosen recommends regular workouts that include weight-bearing aerobic activity, as well as strength training, balance and posture exercises. Additional resources: Osteoporosis bones are porous and weak compared to healthy bones that are more dense. Credit: Shutterstock Medical problems: Numerous health conditions and diseases can also increase a person’s risk for osteoporosis. Medications: Using certain drugs on a long-term basis can lead to bone loss. These medicines include corticosteroids, such as prednisone; heparin, a blood thinner; selective serotonin reuptake inhibitors (SSRIs), a class of antidepressants; and aromatase inhibitors, used to treat breast cancer. Body size: Petite and thin people are at greater risk of this condition because they have less bone to lose than people with larger frames and more body weight. Osteoporosis risk factors The following factors can increase a person’s risk of developing osteoporosis, according to the Cleveland Clinic. Weight-bearing exercise can help keep bones strong and prevent or slow osteoporosis progression. Credit: Shutterstock Learn more about osteoporosis in men from the National Institutes of Health. Unhealthy habits: Smoking and consuming too much alcohol can both increase bone loss. Consuming adequate amounts of foods rich in calcium and vitamin D throughout life. Age: Bones typically become thinner and weaker with age. Osteoporosis symptoms and diagnosis Osteoporosis may cause no symptoms in its early stages, and as a result, the disease can go unnoticed for decades. Some visible signs of osteoporosis may be a loss of height and a curve in the upper back, which may cause stooped posture. A “dowager’s hump” may occur when several vertebrae collapse from osteoporotic fractures in the spine. Other symptoms may include back pain, from a fracture or a collapsed vertebra in the spine, or tooth loss, if osteoporosis has affected the jawbone. Hip fracture is another serious consequence of osteoporosis. About 20% of older adults who fracture a hip die within one year from complications of the broken bone or the surgery needed to repair it, according to the National Osteoporosis Foundation. Doctors may perform a bone mineral density (BMD) test to determine if a patient has osteoporosis, according to the Mayo Clinic. The test uses a special X-ray machine to measure the mineral content at three different bone sites, typically the hip, the spine and the top of the femur. The scan can reveal if a person has low bone mass at any of these three bone sites by comparing the patient’s bone density to the normal bone density in a healthy 30-year-old person of the same sex. BMD testing is recommended for women who are 65 or older and for women 50 to 64 who have certain risk factors for the disease. Men over the age of 70 or younger men with risk factors should also be screened for osteoporosis. read more
A day after the All India Anna Dravida Munnetra Kazhagam (AIADMK) and the BJP inked their seat-sharing formula, the Dravida Munnetra Kazhagam (DMK) and the Congress on Wednesday announced their pre-poll pact to fight the upcoming Lok Sabha elections in Tamil Nadu and Puducherry.Under the agreement, the Congress party has been given nine seats in Tamil Nadu and one in Puducherry.Deciding constituenciesThe two parties finalised only the number of seats under the alliance; the constituencies will be decided after completing the seat-sharing deals with other alliance partners, said DMK President MK Stalin here.He said the DMK would begin its seat-sharing discussion in the coming days with other parties which supported it in taking up various issues in the past two years.Referring to the plans for by-poll for 21 Assembly constituencies, Stalin said the decision would be taken once the Election Commission notifies it.Answering a question on whether there would be a possibility for film actor Vijayakanth-led Desiya Murpokku Dravida Kazhagam (DMDK) to join the DMK-Congress alliance, Stalin indicated there were no talks with the DMDK.It is learnt that the BJP and the DMDK were continuing their discussion for seat-sharing under the AIADMK-BJP alliance, in which the Pattali Makkal Katchi has already sealed a deal.‘Other parties may join’Parties such as the CPI, the CPI(M), the Indian Union Muslim League and the Viduthalai Chiruthaigal Katchi are expected to be part of the DMK-Congress alliance.In 2014, both the DMK and the Congress failed to win any Lok Sabha seat in the State. Tamil Nadu national elections COMMENT Cong gets 9 seats in Tamil Nadu, 1 in Puducherry SHARE Published on February 20, 2019 SHARE SHARE EMAIL COMMENTS read more